Destructive fast check outcomes could delay antiviral remedy in sufferers with extreme influenza (News)


June 10, 2018 – Atlanta, GA – A brand new examine has discovered that half of influenza circumstances in sufferers admitted to the intensive care unit (ICU) acquired a false unfavourable fast influenza antigen check (RIAT). The false unfavourable RIAT outcomes may delay antiviral remedy for sufferers who had been within the ICU with extreme influenza. The analysis is introduced at ASM Microbe, the American Society for Microbiology’s annual assembly, held from June seventh by 11th in Atlanta, Georgia.

The researchers, led by Po-Yen Huang, MD, Chang-Gung Memoria Hospital, Taoyuan,Taiwan, carried out a retrospective evaluation of 307 sufferers with influenza requiring ICU admission at Chang-Gung Memorial Hospital, a tertiary medical heart in Taiwan, from August 2009 to July 2017. Of those 307 circumstances of confirmed influenza, RIAT was carried out on 259 with 126 (49%) testing unfavourable. Among the many 307 circumstances, 45 (15%) both examined unfavourable on all higher respiratory tract (URT) samples or didn’t have URT samples examined. The prognosis of those 45 circumstances as an alternative relied on the exams from decrease respiratory tract (LRT) samples.

RIAT is a well-liked at point-of-care settings because it supplies physicians available outcomes. A constructive check outcome with its excessive specificity confirms the prognosis of influenza. Nevertheless, a unfavourable check outcome and its low sensitivity typically misleads physicians to exclude the influenza prognosis. About half of the circumstances within the examine had unfavourable RIAT outcomes. A considerable portion (15%) of the sufferers had been finally identified solely by testing decrease respiratory tract (LRT) samples. Influenza diagnoses couldn’t be based mostly on the outcomes of RIAT.

“As physicians specialised in infectious illness, we advocate that testing of the LRT samples are essential for prognosis of extreme influenza with crucial sickness,” mentioned Dr. Huang.

In comparison with the RIAT constructive circumstances, the RIAT unfavourable sufferers shared related medical traits besides they required longer ICU stays (median 12 vs. 9 days) and longer ventilator days (median 12 vs. 6 days). Moreover, antiviral therapy was considerably delayed within the RIAT unfavourable sufferers (median 1 vs. zero days).

“Destructive RIAT outcomes delayed therapy with antiviral medicine,” mentioned Dr. Huang, MD. “Choice-making for antiviral medicine based mostly on RIAT outcomes ought to be discouraged. Immediate empiric antiviral medicine ought to be offered to all critically unwell sufferers with extreme respiratory an infection.”


ASM Microbe, the annual assembly of the American Society for Microbiology showcases the most effective microbial sciences on the planet and supplies a one-of-a-kind discussion board to discover the whole spectrum of microbiology. ASM Microbe is held in Atlanta, GA from June 7-11, 2018.

The American Society for Microbiology is the most important single life science society, composed of greater than 30,000 scientists and well being professionals. ASM’s mission is to advertise and advance the microbial sciences.

ASM advances the microbial sciences by conferences, publications, certifications and academic alternatives. It enhances laboratory capability across the globe by coaching and assets. It supplies a community for scientists in academia, business and medical settings. Moreover, ASM promotes a deeper understanding of the microbial sciences to various audiences.

Disclaimer: AAAS and EurekAlert! aren’t liable for the accuracy of News releases posted to EurekAlert! by contributing establishments or for the usage of any data by the EurekAlert system.


Please enter your comment!
Please enter your name here

This site uses Akismet to reduce spam. Learn how your comment data is processed.